主要负责《绿色合成化学》《精细有机合成化学》《精细化工工艺学》《专业实验》等本科课程的教学工作，《绿色合成化学》《精细化工工艺学》课程教学的负责人，参与《有机合成化学》《有机电子学》《大学生创新创业教育》《毕业设计》《基础合成实验》等的教学工作。指导多项省级及校级大学生创新创业项目，并取得优异的成绩。指导的研究生毕业后进入蔚来汽车，江淮汽车，中国石油，长鑫存储，远景动力等企业从事研发工作，本科生进入万华化学，广信农化等企业从事研发工作。
目前主持多项科研项目，包括：国家自然科学基金青年项目（2025-2027），安徽省自然科学基金（2023-2025），教育部“春晖计划”国际合作项目（2023-2025），安徽省博士后科研资助（2023-2025）。
代表性论文如下：
1. Catalytic Asymmetric Mannich Reaction with N-Carbamoyl Imine Surrogates of Formaldehyde and Glyoxylate.
Yang'en You, Long Zhang, Linfeng Cui, Xueling Mi, Sanzhong Luo*, Angew. Chem. Int. Ed., 2017, 56, 13814.
2. Asymmetric Cobalt-Catalyzed Regioselective Hydrosilylation/Cyclization of 1,6-Enynes.
Yang’en You, Shaozhong Ge*, Angew. Chem. Int. Ed. 2021, 60, 12046.
3. Cobalt-Catalyzed One-Pot Asymmetric Difunctionalization of Alkynes to Access Chiral gem-(Borylsilyl)alkanes.
Yang’en You, Shaozhong Ge*, Angew. Chem. Int. Ed. 2021, 20684. (Hot Paper)
4. FeCl3 promoted cycloisomerization of 1,6-dienes.
Zhongjian Du, Chenlei Ji, Xu Wang, Zhenyu Wang, Zhenguo Guo*, Yang’en You*, Org. Chem. Front. 2025, Doi: 10.1039/D4QO02201G.
5. Nickel(II)-Catalyzed Cycloisomerization of 1,6-Dienes.
Zhongjian Du, Chenlei Ji, Xu Wang, Sijian Zhang, Zhenyu Wang, Yang'en You*, Synthesis, 2025, Doi: 10.1055/a-2508-3790.
6. Palladium-catalyzed enantioselective arylation of trichloro- or tri-/difluoroacetaldimine precursors.
Jian Wei, Zhongjian Du, Xu Wang, Chenlei Ji, Longji Li, Yang'en You* Chem. Commun. 2024, 60, 3303.
7. Cs2CO3 Promoted [4 + 2] Cycloaddition of 1, 6-Enynes: An Approach to Tetrahydro-1H-benzo-f-isoindole Isomers.
Xu Wang, Junhao Yin, Wanqing Mao （本科生）, Zhenyu Wang, Shuang Wu, Yang'en You* Org. Lett. 2024, 26, 7757.
8. Electrochemical Dichlorinative Cyclization of 1,n-Enynes by 4-Iodotoluene Catalysis.
Xu Wang, Longji Li, Zhongjian Du, Xingmin Han*, Yang’en You* Org. Lett. 2024, 26, 10583. (第一通讯)
9. Highly effective and selective FeBr3-promoted deuterium bromination/cyclization of 1,n-enynes.
Ping Li, Zhongjian Du, Baofeng Wu, Xin Zhao, Yang'en You* Org. Biomol. Chem. 2024, 22, 959.
10. Regio- and Stereoselective Hydrochlorination/Cyclization of 1,n-Enynes by FeCl3 Catalysis.
Jicheng Hou, Junhao Yin …. Yang’en You*, Org. Lett. 2023, 25, 4359. (第一通讯)
11. Copper-Catalyzed Enantioselective Hydroaminomethylation of Alkenes with N,O-Acetals to Access Chiral β-Stereogenic Amines: Dual Functions of the Copper Catalyst.
Yang’en You, Quyet Van Pham, Shaozhong Ge*, CCS Chem. 2019, 1, 455.
12. Reagent-Controlled Enantioselectivity Switch in Asymmetric Fluorination of β-Ketocarbonyls by Chiral Primary Amine Catalysis.
Yang’en You, Long Zhang, Sanzhong Luo*, Chem. Sci. 2017, 8, 621.
13. Catalytic Asymmetric Mannich Reaction with Trifluoromethyl Aldimines Precursors.
Yang’en You, Sanzhong Luo*, Org. Lett. 2018, 20, 7137.
14. A Scalable and Metal-Free Synthesis of Indazoles from 2-Aminophenones and In Situ Generated De-Boc-Protected O-Mesitylsulfonyl Hydroxylamine Derivatives.
Jinlong Wang, Dongmin Shi, Zihao Wang, Fucai Ren, Xin Li, Yang’en You*, Xinhua Liu*, Yazhou Lou* J. Org. Chem. 2023, 88, 13049.
15. An ultralong single-crystalline nanoporous 3D transition metal-oxo framework nanowire family.
Hao Luo, Cong Lin, Yang-En You, Xue Zhang, Jian Li, Lei Zhang, Junliang Sun*, Zidong Wei*, Jin-Song Hu* Matter, 2023, 6, 3598.
16. Asymmetric Fluorination of α-Branched Aldehydes by Chiral Primary Amine Catalysis: Reagent-controlled Enantioselectivity Switch.
Linfeng Cui, Yang'en You, Xueling Mi*, Sanzhong Luo*, J. Org. Chem. 2018, 83, 4250.
17. Catalytic enantioselective α-sulfenylation of β-ketocarbonyls by chiral primary amines.
Linfeng Cui, Yang'en You, Xueling Mi*, Sanzhong Luo*, Org. Chem. Front., 2018, 5, 2313.
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