Construction of a Chiral Coordination Polymer with Amphiphilic Cavities for Enantioseparation of β-Nitroalcohols
- 影响因子：4.6
- DOI码：10.1021/acs.inorgchem.6c02238
- 发表刊物：Inorganic Chemistry
- 摘要：While the enantiomeric separation of β-nitroalcohols from racemic mixtures is paramount to the manufacture of enantiopure pharmaceuticals, developing chiral separation materials that resolve these compounds with both high enantioselectivity and broad substrate scope remains a massive challenge. Herein, we report a homochiral porous coordination polymer, S-1, constructed from a C2-symmetric phenylalanine-derived ligand with a well-balanced combination of flexibility and rigidity. Assembled with tetrameric Cu4 clusters, S-1 features open channels of 8 Å × 14 Å, in which a confined amphiphilic chiral cavity decorated with peptide functional groups is periodically distributed. When utilized as a chiral adsorbent, this porous material is capable of resolving a series of pharmacologically important aromatic β-nitroalcohols with enantioselectivity up to 99.8%. Furthermore, the chiral adsorbent can be easily recovered and reused for five cycles without any apparent loss of enantioselectivity, demonstrating excellent recyclability. This work not only provides a reliable strategy for constructing amino acid–based porous coordination polymers but also offers a promising platform for targeted β-nitroalcohol resolution.
- 论文类型：期刊论文
- 通讯作者：Zhu chengfeng* et al.
- 学科门类：理学
- 文献类型：J
- 卷号：65
- 页面范围：18730-18737
- ISSN号：0020-1669
- 是否译文：否
- 发表时间：2026-08-17
- 收录刊物：SCI
- 发布期刊链接：https://pubs.acs.org/inocaj/article-pdf/65/32/18730/66418972/acs.inorgchem.6c02238.pdf
附件：
acs.inorgchem.6c02238 (1).pdf
