主要负责《绿色合成化学》《精细有机合成化学》《精细化工工艺学》《专业实验》等本科课程的教学工作，《绿色合成化学》《精细化工工艺学》课程教学的负责人，参与《有机合成化学》《有机电子学》《大学生创新创业教育》《毕业设计》《基础合成实验》等的教学工作。指导多项省级及校级大学生创新创业项目，并取得优异的成绩。指导的研究生毕业后进入蔚来汽车，中国石油，长兴存储，远景动力等企业从事研发工作，本科生进入万华化学，广信农化等企业从事研发工作。

目前主持多项科研项目，包括：国家自然科学基金青年项目（2025-2027），安徽省自然科学基金（2023-2025），教育部“春晖计划”国际合作项目（2023-2025），安徽省博士后科研资助（2023-2025）。

代表性论文如下：

1. Catalytic Asymmetric Mannich   Reaction with N-Carbamoyl Imine Surrogates of Formaldehyde and Glyoxylate.

   Yang'en You, Long Zhang,   Linfeng Cui, Xueling Mi, Sanzhong Luo, Angew.   Chem. Int. Ed., 2017, 56, 13814.

2.  Asymmetric Cobalt-Catalyzed Regioselective Hydrosilylation/Cyclization of 1,6-Enynes. 

   Yang’en You, Shaozhong Ge, Angew. Chem., Int. Ed. 2021, 60, 12046. 

3.  Cobalt-Catalyzed One-Pot Asymmetric Difunctionalization of Alkynes to Access Chiral gem-(Borylsilyl)alkanes.

   Yang’en You, Shaozhong Ge, Angew. Chem., Int. Ed. 2021, 20684. (Hot Paper) 

4. Copper-Catalyzed Enantioselective Hydroaminomethylation of Alkenes with N,O-Acetals to Access Chiral β-Stereogenic Amines: Dual Functions of the Copper Catalyst.

  Yang’en You, Shaozhong Ge, CCS Chem. 2019, 1, 455. 

5.  Reagent-Controlled   Enantioselectivity Switch in Asymmetric Fluorination of β-Ketocarbonyls by Chiral Primary Amine Catalysis. 

  Yang’en   You, Long Zhang, Sanzhong Luo, Chem. Sci. 2017, 8,  621. 

6. Ate   complexes in organic synthesis: From ate reagents to ate catalysts. 

  Yang'en You, Congcong Yin,   Liren Xu, Gen-Qiang Chen*, Xumu Zhang*, Green   Synth. & Catal. 2024, 5, 141. (Review article, front cover)

7. Catalytic   Asymmetric Mannich Reaction with Trifluoromethyl Aldimines Precursors. 

  Yang’en You, Sanzhong Luo, Org.   Lett. 2018, 20, 7137. 

8. Regio-   and Stereoselective Hydrochlorination/Cyclization of 1,n-Enynes by FeCl₃   Catalysis. 

  Jicheng Hou, Junhao Yin …. Yang’en   You*, Org. Lett. 2023, 25, 4359. (第一通讯)

9.   Palladium-catalyzed   enantioselective arylation of trichloro- or tri-/difluoroacetaldimine   precursors. 

  Jian Wei, Zhongjian Du,  Xu Wang, Chenlei Ji, Longji Li, Yang'en   You* Chem. Commun. 2024, 60, 3303. 

10. Cs₂CO₃   Promoted [4 + 2] Cycloaddition of 1, 6-Enynes: An Approach to   Tetrahydro-1H-benzo-f-isoindole Isomers. 

  Xu Wang, Junhao Yin, Wanqing Mao,   Zhenyu Wang, Shuang Wu, Yang'en   You* Org. Lett. 2024, 26, 7757. 

11. Electrochemical   Dichlorinative Cyclization of 1,n-Enynes by 4-Iodotoluene Catalysis. 

  Xu Wang,   Longji Li, Zhongjian Du, Xingmin Han*, Yang’en   You* Org. Lett. 2024, 10.1021/acs.orglett.4c04041.   (第一通讯)

12. Highly   effective and selective FeBr3-promoted deuterium bromination/cyclization of   1,n-enynes. 

  Ping Li, Zhongjian Du, Baofeng Wu, Xin Zhao, Yang'en You* Org.   Biomol. Chem., 2024, 22, 959.  

13.  A   Scalable and Metal-Free Synthesis of Indazoles from 2-Aminophenones and In   Situ Generated De-Boc-Protected O-Mesitylsulfonyl Hydroxylamine Derivatives. 

  Jinlong   Wang, Dongmin Shi, Zihao Wang, Fucai Ren, Xin Li, Yang’en You*, Xinhua Liu*, Yazhou Lou* J. Org. Chem. 2023, 88, 13049. (第二通讯)

14.      An   ultralong single-crystalline nanoporous 3D transition metal-oxo framework   nanowire family.

  Hao   Luo, Cong Lin, Yang-En You,   Xue Zhang, Jian Li, Lei Zhang, Junliang Sun*, Zidong Wei*, Jin-Song Hu* Matter, 2023, 6, 3598.

15.  Asymmetric   Fluorination of α-Branched Aldehydes by Chiral Primary Amine Catalysis: Reagent-controlled   Enantioselectivity Switch. 

  Linfeng Cui, Yang'en   You, Xueling Mi, Sanzhong Luo, J.   Org. Chem. 2018, 83, 4250. 

16. Catalytic enantioselective   α-sulfenylation of β-ketocarbonyls by chiral primary amines. 

  Linfeng Cui, Yang'en You, Xueling Mi,   Sanzhong Luo, Org. Chem. Front., 2018, 5, 2313.